Mechanism of cyclooxygenase-2 upregulation in late preconditioning
نویسندگان
چکیده
منابع مشابه
Cyclooxygenase-2 mediates the cardioprotective effects of the late phase of ischemic preconditioning in conscious rabbits.
We examined the role of cyclooxygenase-2 (COX-2) in the late phase of ischemic preconditioning (PC). A total of 176 conscious rabbits were used. Ischemic PC (six cycles of 4-min coronary occlusions/4-min reperfusions) resulted in a rapid increase in myocardial COX-2 mRNA levels (+231 +/- 64% at 1 h; RNase protection assay) followed 24 h later by an increase in COX-2 protein expression (+216 +/-...
متن کامل-Opioid receptor-induced late preconditioning is mediated by cyclooxygenase-2 in conscious rabbits
Kodani, Eitaro, Yu-Ting Xuan, Ken Shinmura, Hitoshi Takano, Xian-Liang Tang, and Roberto Bolli. -Opioid receptor-induced late preconditioning is mediated by cyclooxygenase-2 in conscious rabbits. Am J Physiol Heart Circ Physiol 283: H1943–H1957, 2002. First published July 26, 2002; 10.1152/ajpheart.00150.2002.—Although activation of -opioid receptors is known to induce both early and late preco...
متن کاملDelta-opioid receptor-induced late preconditioning is mediated by cyclooxygenase-2 in conscious rabbits.
Although activation of delta-opioid receptors is known to induce both early and late preconditioning (PC) against myocardial infarction, the mechanisms for this salubrious effect are unclear. Furthermore, it is unknown whether delta-opioid receptors can also induce late PC against myocardial stunning. By using conscious rabbits (n = 120) in this study, we found that the delta-opioid receptor ag...
متن کاملCyclooxygenase-2 does not mediate late preconditioning induced by activation of adenosine A1 or A3 receptors.
Recent studies have demonstrated that the adenosine A1 receptor agonist 2-chloro-N6-cyclopentyladenosine (CCPA) and the adenosine A3 receptor agonist N6-(3-iodobenzyl)adenosine-5'-N-methyluronamide (IB-MECA) produce a delayed phase of protection against infarction similar to the late phase of ischemic preconditioning (PC). However, the mechanism for adenosine A1 or A3 receptor-induced late PC r...
متن کاملIL-6 plays an obligatory role in late preconditioning via JAK-STAT signaling and upregulation of iNOS and COX-2.
OBJECTIVE We sought to determine whether interleukin (IL)-6 modulates myocardial infarction or the late phase of preconditioning (PC). METHODS Wild-type and IL-6(-/-) mice underwent a 30-min coronary occlusion followed by 24 h of reperfusion with or without six cycles of coronary occlusion/reperfusion 24 h earlier. Myocardial IL-6 protein expression, activation of Janus kinase (JAK) 1 and JAK...
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ژورنال
عنوان ژورنال: Journal of Molecular and Cellular Cardiology
سال: 2003
ISSN: 0022-2828
DOI: 10.1016/s0022-2828(03)00076-2